Chondrocyte function
WebIn contrast, high expression of NFAT1 in articular chondrocytes of young adult mice suggests that NFAT1 is required for maintenance of chondrocyte function in adults; thus, lack of Nfat1 expression in adult mice causes severe dysfunction of articular chondrocytes and subsequent OA [22]. Epigenetic analyses demonstrated that an increase in NFAT1 ... WebPrevailing evidence indicates that the histone-modifying proteins that regulate chondrocyte anabolic or catabolic gene expression programs in cartilage are instrumental in determining chondrocyte fate and …
Chondrocyte function
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WebJan 26, 2005 · Deterioration in chondrocyte function accompanies these changes in the extracellular matrix . Recently, attention has been given to the suggestion that cartilage ageing and chondrocyte senescence play an important role in the pathogenesis and development of osteoarthritis (OA) [4, 5]. WebChondrocyte degeneration in OA has been described in very early studies that analyzed cartilage at the ultrastructural level. 29 Although useful in providing general descriptive data, these ...
WebDec 27, 2024 · 3.2. Exosomes Affect Cell Function and Glutamine Metabolism of OA Chondrocytes. To determine whether there are differences in the cell function and glutamate metabolism between the control, OA, and OA+exosome groups, we established the OA rat chondrocyte model in vitro.Cell apoptosis rate was identified by flow cytometry. WebChondrocyte culture is an efficient target system for evaluation of the pharmacological and toxicological effects of drugs acting on cartilaginous tissue. Many types of culture exist …
WebJul 11, 2024 · Here, we summarised the literature findings on the role of cellular metabolism in determining the chondrocyte function and how this metabolic dysregulation led to cartilage aging in OA and provided an outlook on how the field may evolve in the coming years. Although the various energy metabolism pathways are inextricably linked with one … WebNov 25, 2024 · Chondrocytes are the only cell type in normal cartilage. The pathological changes of osteoarthritis (OA) mostly revolve around the apoptosis and dysfunction of chondrocytes. Autophagy, as an intracellular degradation system that maintains the steady state of energy metabolism in cells, has been shown to restore the function of damaged …
WebChondrocytes – Location and Function Fibro-cartilage – part of vertebral disc and knees. Chondrocytes are present here in few numbers and hence it is the... Hyaline cartilage – …
WebGrowth plate chondrocytes survive and function in an avascular environment, but their nutritional requirements are poorly characterized. Stegen et al. now demonstrate that the key chondrogenic transcription factor SOX9 induces glutamine metabolism, and this metabolic adaptation is in turn necessary to support chondrocyte gene expression, … bangkirai oder wpcWebThe cells of cartilage, called chondrocytes, are isolated in small lacunae within the matrix. Although cartilage is avascular, gaseous metabolites and nutrients can diffuse through … aryan deshwalWeb3.2 Chondrocyte Cell Lines As Models for Studying Chondrocyte Function. Immortalized chondrocyte cell lines serve as reproducible models to study the expression of chondrocyte-specific matrix genes and to examine the effects of cytokines and growth/differentiation factors on chondrocyte phenotypic markers, as shown in Figs. 1 … aryan cargoWebApr 13, 2024 · To deeply investigate the regulatory mechanism of circRNAs in antler regeneration, we identified a new circRNA2829 differentially expressed in two tissues … aryan deshpandeWebNational Center for Biotechnology Information bangkirai öl 5lWebSkeletal growth by endochondral ossification involves tightly coordinated chondrocyte differentiation that creates reserve, proliferating, prehypertrophic, and hypertrophic … bangkirai öl 016WebBackground: SOX9 is essential for cartilage.Results: miR-145 directly targets SOX9, and increased miR-145 levels reduce expression of SOX9 and the extracellular matrix genes critical to cartilage function.Conclusion: SOX9 is subject to significant post-transcriptional regulation by miR-145 in human chondrocytes.Significance: Our data give new insights … aryan diaper