Rsl3 solubility
WebSolubility (25°C) Chemical Information Download Liproxstatin-1 SDF In vivo Formulation Calculator (Clear solution) Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment) Dosage: mg/kg Average weight of animals: g Dosing volume per animal: μL Number of animals: WebSolubility Data for 1S,3R-RSL3 Preparing Stock Solutions for 1S,3R-RSL3 The following data is based on the product molecular weight 440.88. Batch specific molecular weights may …
Rsl3 solubility
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Web1R,3R-RSL3 is a negative control for 1S,3R-RSL3 (Cat. No. 6118). Technical Data. M.Wt: 440.88. Formula: C 23 H 21 ClN 2 O 5. Solubility: Soluble to 100 mM in DMSO. Purity: ≥98%. Storage: Store at -20°C. CAS No: 1219810-15-7. The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. WebMar 1, 2024 · RSL3 ( (1S,3R)-Methyl 2- (2-chloroacetyl)-2,3,4,9-tetrahydro-1- [4- (methoxycarbonyl)phenyl]-1H-pyrido [3,4-b]indole-3-carboxylate) ( Fig. 2) was first identified in a high-throughput screening as a compound that can selectively induce non-apoptotic, iron-dependent, oxidative cell death in transformed cells harboring activated H-Ras. 67 …
Web(1S,3R)-RSL3: Storage: 3 years -20°C powder 1 years -80°C in solvent Formula: C 23 H 21 ClN 2 O 5. Molecular Weight: 440.88: CAS No. 1219810-16-8: Solubility (25°C) * In vitro: DMSO ... * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is ... WebDec 15, 2024 · The region around cysteine 66 (C66) is an allosteric binding site of RSL3 on GPX4 • C66 modulates the enzymatic activity of GPX4 • Covalent binding of compounds to C66 inhibits and degrades GPX4 • Co-crystal structures of six distinct compounds covalently binding to C66 are reported Summary
WebSolubility: ≥ 0.56 mg/mL (1.27 mM); Clear solution 5. BIOLOGICAL ACTIVITY Description RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head … Web(1S,3R)-RSL3 is soluble in organic solvents such as ethanol, DMSO and dimethyl formamide (DMF). The solubility of (1S,3R)-RSL3 in ethanol is approximately 25 mg/ml and …
WebRSL3 is identified as a potent ferroptosis-triggering agent, which is dependent on the activity of GPX4. RSL3 behaved as an inhibitor of GPX4, reducing the expression of GPX4 and …
WebFeb 1, 2024 · And the classic ferroptosis agonist (RSL3) with low specificity for tumors, short half-life in the blood, poor water solubility and deficient accumulation at the tumor … how to people in an emailWebJul 13, 2024 · RSL3 irreversibly inhibits the phospholipid hydroperoxidase glutathione peroxidase 4 (GPX4) [7, 8], a selenoenzyme that functions by reducing hydroperoxide … my book power supplyWebAug 1, 2024 · Both erastin and RSL3 cause the loss of cellular antioxidant capacity, leading to ferroptosis [8, 10]. Ferroptosis inducers can act alone or with chemotherapy drugs (e.g., temozolomide, cisplatin, ... (1-Methoxy PMS) to a yellow formazan dye with high water solubility. Absorbance at 450 nm is proportional to the number of living cells in the ... how to people in outlook emailWebMar 14, 2024 · It was coined recently in 2012 by Stockwell Lab members, who described a special kind of cell death induced by erastin or RSL3. Ferroptosis is characterized by alterations in oxidative status resulting from iron accumulation, increased oxidative stress, and lipid peroxidation, which are mediated by enzymatic and non-enzymatic pathways. how to people in outlookWebMar 30, 2024 · As for RSL3 and ML162, treatment of cells with ML210 results in the accumulation of cellular lipid hydroperoxides whose lethal effects can be prevented by cotreatment with the radical-trapping... my book premium storage 4tbWebNov 22, 2024 · Here, we showed that ferroptosis inducer RSL3 initiated cell death and ROS accumulation in HCT116, LoVo, and HT29 CRC cells over a 24 h time course. Furthermore, we found that ROS levels and transferrin expression were elevated in CRC cells treated with RSL3 accompanied by a decrease in the expression of glutathione peroxidase 4 (GPX4 ... how to people learnWeb[活性氧物种]Cu-ATSP-德尔塔(Delta)生物试剂定制生产，产品长期供货。[活性氧物种]Cu-ATSP-德尔塔(Delta)生物试剂仅用于科研。[活性氧物种]Cu-ATSP-德尔塔(Delta)生物试剂不能用于人体治疗、药物开发、和其他商业用途。如果需要采购[活性氧物种]Cu-ATSP-德尔塔(Delta)生物试剂，请联系我们：18133906270 how to people in email outlook